College Station, Texas - C3B® researchers announced the filing of a provisional patent for an original and novel hemorrhage survivability score, and algorithm for establishing that score, that could contribute to saving lives in our ERs and in far-forward battlefield hospitals. Drawing upon their work on the physiological status monitoring biochip - The "PSM Biochip" TEES researchers now exstablish the "Hemorrhage Intensive Severity and Survivability (HISS) Score" for hemorrhaging trauma patents.
The HISS Score for hemorrhaging trauma patents fuses five easily and rapidly measured physiological biomarkers to yield an actionable response that is intended to guide resuscitation and reanimation of the succumbing patient. The contributing inventors, Dr. Ankita Bhat, Dr. John Aggas and Dr. Brandon Walther were led by Prof. Anthony Guiseppi-Elie of Texas A&M Engineering Experiment Station (TEES).
Read the published paper.
Ankita Bhat, Daria Podstawczyk, Brandon K. Walther, John R. Aggas, David Machado-Aranda,Kevin R. Ward, and Anthony Guiseppi-Elie “Toward a Hemorrhagic Trauma Severity Score: Fusing Five Physiological Biomarkers” Journal of Translational Medicine (2020)18, 348.
Key Paper
College Station, Texas - Professor Guiseppi-Elie, serving as the Founding convening Chair, successfully completed the first-ever Center for Bioelectronics, Biosensor and Biochips Virtual Scientific Meeting (C3B®-20) via Zoom®. Organized under the auspices of the United Scientific Group, the three hour C3B-20 Meeting was held on May 29th, 2020, convening at 08:45 AM Eastern Time (US and Canada).
Attended by as many as 40 registered participants, the meeting was moderated by Dr. Hua Xiao “Adam” Yang of the Stanford Cardiovascular Institute and featured a keynote presentation by Prof. Anthony Guiseppi-Elie on Multiplexed Microanalytical Biosensor Systems. Additional presentations included a featured presentation by Dr. Ajeet Kaushik, Assistant Professor of Chemistry, Florida Polytechnic University who spoke on “Smart Biosensor for Personalized Health Care”. Other speakers included Mr. Zachary Bujnoch, an independent consultant, who spoke on “Making A Technology A Solution: Considerations and Methodologies For Transitioning A Technology Into A Minimal Viable Product”; Dr. Yun Tian, Associate Professor, Eastern Washington University, who spoke on “Word Extract Associations Between Biomedical Concepts From Large Text Data Set In Cloud” and Dr. Hua Xiao “Adam” Yang of Stanford University who spoke on “Micropatterned Human Pluripotent Stem Cell-Derived Biochip for Cardiac Maturation and Disease Modeling”. In addition to the high profile presenters, the meeting also featured the work of two young researchers, Mr. Kasyap Chakravadhanula, of BASIS® Scottsdale High School, AZ, who spoke on “An Inexpensive Smartphone-Based Device for Rapid, Non-Invasive, and Point-of-Care Monitoring of Diabetes with Related Ocular and Cardiovascular Complications” and Mr. MD Hasan Anowar of the University of Texas Rio Grande Valley, TX, who spoke on “An Open Source Python App for Sleep Data Analysis”.
“The meeting was a great success for community morale, collaboration and team building”, said Prof. Guiseppi-Elie. “Moreover, it established United Scientific as a major player in the emerging on-line conference market”. “The meeting was a great way to stay connected and learn of progress from our colleagues all around the world without leaving home,” said Prof. Rossanna Madrid of The University of Tucumán, Argentina.
Established in September 2008, The Center for Bioelectronics, Biosensors and Biochips is an on-line community of scholars, researchers, developers and entrepreneurs established on LinkedIn to support the development and commercialization of human health applications of bioelectronics, biosensors and biochip technologies.
College Station, Texas - Professor Guiseppi-Elie, PI of the Center for Center for Bioelectronics, Biosensor and Biochips, sat down with CareDash to answers questions about his work on the physiological status monitoring biochip - The "PSM Biochip". Here are the results of that interview.
New Biochip Tech Shows Promise in Traumatic Hemorrhage Outcomes
Story details are at CareDash:
Congratulations to Dr. Sara Abasi and Dr. Ankita Bhat who were both celebrated yesterday (Friday, May 8th) at the Biomedical Engineering’s Department’s Graduation Ceremony where they were both granted their doctoral diplomas (virtually) for the earned doctor of philosophy.
Release From Degrading Hydrogel And Electrostimulation: Toward A Biomimetic Environment For Endothelial Cells
Dr. Sara Abasi
Thank you so much, professor. I am so proud to have been your student, words can’t express my full gratitude. Thanks for all your support over the last five years. Your impact will last a lifetime. Thank you.
Sara Abasi
Multi-analyte Biosensor for Physiological Status Monitoring During Hemorrhage
Dr. Ankita D. Bhat
Thank you so much, Dr. G-E! Heartfelt thanks to you for your help, support, and guidance over the course of my doctoral studies. Greatly appreciated.
C3Bers: Thanks for being such a fantastic group! It has been a pleasure working with you. Best wishes to each of you. Thank you.
Ankita Bhat
Two doctoral candidates from the C3B® Lab Group are scheduled to defend their doctoral dissertations for May 2020 graduation.
Release From Degrading Hydrogel And Electrostimulation: Toward A Biomimetic Environment For Endothelial Cells
Ms. Sara Abasi, MS(BMEN)
ETB 5039, 12:00 pm - 2:00 pm
Tuesday, February 25th, 2020
COMMITTEE:
Prof. Anthony Guiseppi-Elie, Chair, BMEN
Prof. Melisa Grunlan, Member, BMEN
Dr. Abhishek Jain, Member, BMEN
Prof. Svetlana Sukhishvili, Member, MSEN
Multi-analyte Biosensor for Physiological Status Monitoring During Hemorrhage
Ms. Ankita D. Bhat, MS(BMEN)
ETB 5039, 12:00pm - 2:00pm
Thursday, February 27th, 2020
COMMITTEE:
Prof. Anthony Guiseppi-Elie, Chair, BMEN
Prof. Michael McShane, Member, BMEN
Dr. Abhishek Jain, Member, BMEN
Prof. Edgar Sanchez-Sinencio, Member, ECEN
Two undergraduates from the C3B® Lab Group attended and presented at the Biomedical Engineering Society’s Annual Meeting this year in Philadelphia, Pennsylvania.
Iris Vallavanatt (BIOL ’21), who worked with 4th year doctoral student Sara Abasi, presented her poster entitled, “Culture of HUVEC Monolayer and Effect of Tight Junction Formation on Impedance” in the undergraduate poster session. The formation of tight junctions is associated with growth to confluency of the HUVEC monolayer. Tight junction formation was visualized by staining VE-cadherin, an associated protein, to confirm the presence of tight junctions. These junctions impede ion transport between adjacent cells which can be monitored via resistance/impedance changes in ECSARA, a 24 well electroculture ware plate device designed and developed in the C3B® lab. Both results of standard alamarBlue viability assay and impedance spectroscopy showed a faster growth of EF-stimulated cells compared to the control. Therefore, a direct relationship between tight junction formation, growth to confluence, and cell resistance and capacitance exists. These parameters can be measured in real time with electrical impedance spectroscopy (EIS). Ms. Vallavanatt also volunteered at the registration desk and had the opportunity to speak with representatives from Texas A&M’s EnMed program while at BMES.
Ryan Davis (BMEN ’20), who also worked with 4th year doctoral student Sara Abasi, presented his poster entitled, “Degradation Profile and Release Kinetics of poly(HEMA-co-HPMA-co-GelMA) Hydrogel” in the undergraduate poster session. The cross-linking of HEMA-co-HPMA with methacrylated gelatin (GelMA), a modified natural polymer, gives rise to a biohybrid polymer capable of matrix metalloproteinases (collagenase) degradation. Such a polymer could be tuned to take advantage of the balance between diffusive and bio-errosive release of factors. Using FITC-dextran (40kDa) as an example, Ryan measured and modeled both the degradation kinetics and release kinetics showing the domain of influence of the studied principles of release at difference level of GelMA inclusion. Ryan visited and held discussions with several graduate schools who had representatives in attendance and renewed his commitment to attend graduate school in the Fall of 2020.
Professor Anthony Guseppi-Elie was recently selected to serve as a keynote speaker at the AfroBiotech Conference 2019 in Atlanta, GA from Oct. 27-29. The AfroBiotech Conference, hosted by the Society for Biological Engineering (SBE) of the American Institute of Chemical Engineers (AIChE), will highlight the achievements of African Americans in biotechnology, inspire a new generation of diverse biotechnology professionals and identify, communicate, and explore current advancements in various aspects of Biotechnology. Prof. Guiseppi-Elie recently shared his excitement on LinkedIn:
"Deeply honored and privileged to be selected as a #keynote speaker at the AfroBiotech Conference 2019. Hosted by the Society for Biological Engineering of the American Institute for Chemical Engineers (#LifeMember) and organized by Georgia Tech @ManuPlatt and Emory University @KarmellaHaynes, this conference features some of our nation’s top academic, industrial and publicly serving scientist, engineers and technologist in medical and biological engineering. Join us…"
Ms. Sara Abasi, Ms. Ankita Bhat, and Mr. Brandon Walther presented their graduate work at the 2019 Biomedical Engineering Graduate Student Association's Research Symposium on August 21, 2019 in the Zachry Engineering Complex at Texas A&M University. Ms. Abasi and Ms. Bhat presented long-form oral presentations. Brandon Walther, a MD-PhD student jointly directed by Prof. Guiseppi-Elie of the C3B® and Dr. John Cooke of the HMRI Cardiovascular Sciences Department has won second place among poster presenters of the 5-min Rapid Fire Talks at the 3rd Annual Research Symposium 2019 (BMEGSA) for the flash presentation entitled “Biosensor Enabled Microvasculature-on-a-Chip”. This work is groundbreaking and potentially impactful engineering work.
Ms. Sara Abasi has recently published a paper titled "Biotechnical Properties of Poly(HEMA-co-HPMA) in ACS Biomaterials. Hydrogels are Governed by Distribution among Water States" along with co-authors Dr. Daria Podstawczyk, Alycia Sherback, and Dr. Anthony Guiseppi-Elie. This paper show that it is the partitioning of water among freezable and non-freezable states that govern all the major biomedical properties of hydrogels - not the total hydration.
C3B graduate students, Sara Abasi, John Aggas and Ankita Bhat, had a wonderful experience serving as mentors at the Aggies Invent-EnMed at Texas A&M University on June 28-30, 2019. Congratulations to all the 13 teams for their incredible efforts towards solving engineering problems in 48 hours! This was the first ever Aggies Invent (ENMED edition) at Texas A&M’s College of Engineering that was organized and lead by Prof. Anthony Guiseppi-Elie, Associate Dean, Engineering Innovation, ENMED. Aggies Invent is Texas A&M’s 48-hour intensive design experience wherein multidisciplinary teams of students competitively hone their innovation, creativity and communication skills. ENMED is Texas A&M’s innovation-centered medical school option in the Texas Medical Center. Our specifically mentored team, VesselTech, which worked on Microvasculature Perfusion System, received the second place prize in this competition for their intense design experience.
Ms. Lauren Whitney, a Master's student in the Center for Bioelectronics, Biosensors, and Biochips (C3B®) by Dr. Guiseppi-Elie in the Department of Biomedical Engineering at Texas A&M University, has successfully defended her thesis titled: Electroconductive hydrogel nanocomposites of Gelatin|PLGA|PPy:PSS for cardiac tissue regeneration.
Mr. John Aggas, a doctoral student in the Center for Bioelectronics, Biosensors, and Biochips (C3B®) by Dr. Guiseppi-Elie in the Department of Biomedical Engineering at Texas A&M University, has successfully defendid his dissertation titled: Biologically Responsive Soft Circuit Elements: Towards Implantable Bioelectronics.
Dr. Anthony Guiseppi-Elie has been appointed full affiliate member of the Houston Methodist Research Institute (HMRI). Recommended by the board of directors of the institute and appointed to the Department of Cardiovascular Sciences, Guiseppi-Elie assumed his appointment March 1. He was also appointed adjunct professor of biomedical engineering in the Department of Cardiovascular Sciences within the Houston Methodist Institute for Academic Medicine (IAM), effective April 1.
“Tony is a highly collaborative scientist/engineer who brings a wealth of experience in the design, development and application of chemical and biological sensors to challenges in human health. We welcome Tony’s participation with our department and within the HMRI broadly,” said Dr. John P. Cooke, chairman of cardiovascular science at HMRI and the IAM.
Guiseppi-Elie is associate dean of engineering medicine (EnMed) at Texas A&M University. He is currently a TEES Research Professor and professor in the Department of Biomedical Engineering with a courtesy appointment in the Department of Electrical and Computer Engineering. EnMed is Texas A&M’s innovative engineering medicine school option at Houston Methodist Hospital, developed to educate a new kind of physician to create transformational technology for health care.
Ms. Ankita Bhat, a third-year doctoral student in the Center for Bioelectronics, Biosensors, and Biochips (C3B®) by Dr. Guiseppi-Elie in the Department of Biomedical Engineering at Texas A&M University, has received the prestigious National Science Foundation (NSF) fellowship to attend the 18th NSF International Summer School (2019) on Bio-X: Biocomplexity, Biodesign, Bioinnovation, Biomanufacturing and Bioenterprenuership. The 2019 summer school will be held in the Mediterranean city of Chania, on the island of Crete, from June 9-15. The fellowship will cover all the local accommodations for the student while studying in Greece. Ankita’s research involves the development of implantable biochips for physiologic status monitoring. This includes nano-enabled bio-interfaced electroconductive biosensors and biochips for the study of the complex pathophysiology of trauma-induced hemorrhage. Her research incorporates the integration of biotransducers, mixed-signal electronics, low power devices, and wireless communications into clinically relevant systems for monitoring during trauma and surgery and for monitoring in the intensive care unit (ICU). “I am excited about this global opportunity associated with the elite NSF fellowship. The Summer School will enable me to network and establish connections with participating faculty and students in the area of biosensors. I will also like to present my research and learn from others conducting research in the area of design, manufacturing, innovation, and entrepreneurship related to biosensors. This will be a wholesome experience.” said Ankita.
C3B had a successfull year publishing papers on our work. See the list of papers below:
Aggas, John R., et al. "Metal–polymer interface influences apparent electrical properties of nano-structured polyaniline films." Nanoscale 10.2 (2018): 672-682.
Aggas, John R., Jodie Lutkenhaus, and Anthony Guiseppi‐Elie. "Chemiresistive and Chemicapacitive Devices Formed via Morphology Control of Electroconductive Bio‐nanocomposites." Advanced Electronic Materials 4.2 (2018): 1700495.
Kotanen, Christian N., et al. "Fabrication and in vitro performance of a dual responsive lactate and glucose biosensor." Electrochimica Acta 267 (2018): 71-79.
Amanor-Boadu, J., A. Guiseppi-Elie, and E. Sánchez-Sinencio. "The Impact of Pulse Charging Parameters on the Life Cycle of Lithium-Ion Polymer Batteries." Energies 11.8 (2018): 2162.
Amanor-Boadu, Judy M., Anthony Guiseppi-Elie, and Edgar Sánchez-Sinencio. "Search for optimal pulse charging parameters for Li-Ion polymer batteries using Taguchi orthogonal arrays." IEEE Transactions on Industrial Electronics 65.11 (2018): 8982-8992.
Mistewicz, Krystian, et al. "Ferroelectric SbSI nanowires for ammonia detection at a low temperature." Talanta 189 (2018): 225-232.
Aggas, John, et al. "Microfabricated and 3-D Printed Soft Bioelectronic Constructs from PAn-PAAMPSA-Containing Hydrogels." Bioengineering 5.4 (2018): 87.
Dr. Anthony Guiseppi-Elie has been named associate dean of Engineering Medicine (EnMed) at Texas A&M University. He is currently a TEES Research Professor and professor in the Department of Biomedical Engineering with a courtesy appointment in the Department of Electrical and Computer Engineering. EnMed is Texas A&M University’s innovative engineering medicine school option at Houston Methodist Hospital, developed to educate a new kind of physician to create transformational technology for health care. “I welcome the opportunity to represent the college of engineering on the leadership of EnMed and to work closely with my colleagues in the college of medicine and at Houston Methodist Hospital to realize one of Texas A&M’s most ambitious undertakings as we continue to lead the world with innovative academic programs intended to impact patient outcomes,” said Guiseppi-Elie.Guiseppi-Elie is world-renowned researcher whose interests are in engineered bioanalytical microsystems in the service of human health and medicine. This includes bionanotechnology, microfabrication and 3D printing of bio- and electroresponsive hydrogels, BioMEMS, physiology-on-a-chip, ABIO-BIO interfaces, and interfacing of biology and engineering at the molecular, cellular and tissue length scales. He has published more than 150 archival scientific papers, 31 books or proceedings chapters, holds eight U.S. and foreign patents and has given over 200 invited lectures. He is an editor-in-chief of Bioengineering, an associate editor of Biomedical Microdevices and a member of the editorial boards of The Journal of Bioactive and Compatible Polymers, NanoBiotechnology, and Applied Biochemistry and Biotechnology. He has been a guest editor for the Institute of Electrical and Electronics Engineers (IEEE) Journal of Biomedical and Health Informatics.Guiseppi-Elie is a Fulbright Specialist Award recipient in bioengineering at the University of Tucumán in Tucumán, Argentina, and has been an IEEE-Engineering in Medicine and Biology Society Distinguished Lecturer. He is a fellow of the American Institute of Medical and Biological Engineering, the Royal Society of Chemistry and IEEE, a lifetime member of the American Institute of Chemical Engineers and holds memberships in many other prominent organizations. Guiseppi-Elie will assume his new role on Dec. 3.
Ms. Ankita Bhat, a doctoral student in the Bioelectronics, Biosensors and Biochips laboratory of TEES Research Professor, Dr. Anthony Guiseppi-Elie, has received a prestigious Goa Scholars Award from the Government of Goa, India. The Goa scholars scheme was started in the year 2003-04 and since its inception, around 20 Goan students have been awarded the prestigious 'Goa Scholar' scholarships each year. The Goa Scholars Award is accompanied by a one-time US $20,000 award for studies at Texas A&M University. Ms. Bhat’s doctoral work focuses on the development of minimally-invasive, multi-analyte biosensor arrays and data fusion for the management of trauma associated hemorrhage. Her multi-disciplinary engineering and medicine research allows her to apply engineering principles and know how to address pressing problems in patient care. “Our goal is to better understand hemodynamics of the bleeding patient so that we may develop better and even personalized approaches to resuscitation and reanimation,” said Prof. Guiseppi-Elie. “The prestige associated with this award is great, it is a great honor and responsibility” said Ankita.
Professor Guiseppi-Elie served as the Organizing Chair for the Spring 2018 EnMed Lasker Lecture and Biomedical Imaging Symposium (https://enmed.tamu.edu/lasker-lecture-biomedical-imaging-symposium/) on April 25-26 in the Houston Medical Center. EnMed, a partnership between the Texas A&M University College of Engineering, College of Medicine and Houston Methodist Hospital, is an innovative integrated educational and research medical program with a focus on innovation and entrepreneurship.
John Aggas, a doctoral student in the Guiseppi-Elie Lab of the Center for Bioelectronics, Biosensors and Biochips in the Department of Biomedical Engineering at Texas A&M University, received a National Science Foundation (NSF) fellowship to attend the 16th NSF International Summer School (2017) on Bio-X: Biocomplexity, Biodesign and Bioinnovation.
Aggas started at Texas A&M in the spring of 2016 and is in his third semester. Currently he is pursuing research in the field of biologically responsive and biocompatible polymeric circuit elements for implantable biosensing.
His research consists of utilizing a conductive nanofiber synthesized from polyaniline that is dispersed within a hydrogel to develop both resistive and capacitive circuit elements. These elements, when integrated with biological recognition molecules such as enzymes, can demonstrate a biological response to physiological metabolites, such as glucose or lactate. The result is the ability to create organic circuits that signal levels of lactate and glucose.
